Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance.They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule CD1d.The structure of human iNKT TCRs is unique in that only one of the six complementarity dete